Storage and Handling of Sildenafil 60mg Tablets
Tell your healthcare provider about all of the medicines you or your child take, including prescription and overthe- counter medicines, vitamins, and herbal supplements. REVATIO and certain other medicines may affect each other and can cause side effects.
Comparing Drug Interactions
It is not known if REVATIO is safe in people with bleeding problems or who have a stomach ulcer. have an eye problem called retinitis pigmentosa have ever had sudden loss of vision in one or both eyes, including an eye problem called non-arteritic anterior ischemic optic neuropathy (NAION) have ever had hearing problems such as ringing in the ears, dizziness, or loss of hearing have a deformed penis shape or Peyronie’s disease have any blood cell problems such as sickle cell anemia are pregnant or plan to become pregnant. It is not known if REVATIO will harm your unborn baby. It is not known if it can harm your baby. Talk with your healthcare provider about the best way to feed your baby during treatment with REVATIO. Especially tell your healthcare provider if you or your child take: See “What is the most important information I should know about REVATIO?” REVATIO contains sildenafil, which is the same medicine found in another medicine called VIAGRA®.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 200mg | 180 + 10 Pills | 277.56€ 264.34€ | |
| Kamagra | 100mg | 12 Pills | 55.64€ 52.99€ | |
| Kamagra Oral Jelly | 100mg | 30 + 5 Sachets | 136.20€ 129.71€ | |
| Viagra Generic | 25mg | 120 + 6 Pills | 125.56€ 119.58€ | |
| Viagra Generic | 25mg | 90 + 6 Pills | 105.03€ 100.03€ | |
| Kamagra Oral Jelly | 100mg | 21 Sachets | 95.92€ 91.35€ | |
| Kamagra Oral Jelly | 100mg | 220 + 18 Sachets | 662.24€ 630.70€ | |
| Viagra Generic | 25mg | 30 + 4 Pills | 47.97€ 45.69€ | |
| Viagra Generic | 200mg | 270 + 10 Pills | 379.76€ 361.68€ | |
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ | |
| Viagra Generic | 50mg | 60 + 4 Pills | 83.93€ 79.93€ | |
| Viagra Generic | 150mg | 360 + 10 Pills | 423.48€ 403.31€ | |
| Viagra Generic | 100mg | 270 + 10 Pills | 270.47€ 257.59€ | |
| Kamagra | 100mg | 60 + 4 Pills | 201.34€ 191.75€ | |
| Kamagra Polo | 100mg | 120 + 6 Pills | 327.15€ 311.57€ | |
| Kamagra Polo | 100mg | 180 + 8 Pills | 446.52€ 425.26€ |
VIAGRA is used for the treatment of erectile dysfunction.
The Takeaway
It is not known if REVATIO is safe and effective in children younger than 1 year of age. Do not take REVATIO if you or your child: take riociguat, a guanylate cyclase stimulator medicine. are allergic to sildenafil or any of the ingredients in REVATIO. See the end of this leaflet for a complete list of ingredients in REVATIO. Before taking REVATIO, tell your healthcare provider about all of your medical conditions, including if you or your child: have bleeding problems or a stomach (peptic) ulcer. Do not take VIAGRA or other PDE-5 inhibitors during treatment with REVATIO. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.
Further information
An additional secondary endpoint was 6MWD at Months 6 and 12. At the time of a planned interim analysis (50% deaths) it was identified that the primary efficacy objective of this protocol was met and therefore the study was stopped. Based on the primary efficacy endpoint (mortality), the non-inferiority of sildenafil 80 mg TID arm versus 5 mg TID arm was met using a 2-sided significance level of 0.003 for the interim analysis. Primary comparison of the 80 mg TID group to the 5 mg TID group yielded the HR (99.7% CI) = 0.51 (0.22, 1.21); i.e., non-inferiority was established. Table 6: Hazard Ratios for Overall Survival, Assessed in the Proportional Hazards Model – Intent To Treat Population Kaplan-Meier estimates of survival at 3 years were 66%, 79%, and 85% in the 5-, 20-, and 80- mg TID dose groups, respectively.
Is Viagra dosage based on age or weight?
Sildenafil 80 mg was also superior to 5 mg for time to first event of clinical worsening with HR (99.7% CI) = 0.44 (0.22, 0.89). Table 7: Hazard Ratios for Time to First Event of Clinical Worsening – Intent To Treat Population At baseline, the median of 6MWD for the intent-to-treat (ITT) population was 332 to 352 m. At Month 6, the median change from baseline was highest for sildenafil 80 mg TID with 28 m compared to 18 m and 19 m for sildenafil 5 mg TID and sildenafil 20 mg TID groups, respectively. The same was seen at Month 12, the median change from baseline for sildenafil 80 mg TID group was 33 m compared to 17 m for sildenafil 5 mg TID and 31 m in sildenafil 20 mg TID groups. Overall, the safety data for sildenafil 20 mg TID and for the higher sildenafil 80 mg TID dose were consistent with the established safety profile of sildenafil in previous adult PAH studies [see ADVERSE REACTIONS]. Know the medicines you or your child take.
- Sildenafil 60mg is used to treat erectile dysfunction.
- It works by relaxing blood vessels to increase blood flow.
- The usual dosing frequency is once a day.
- Do not take more than one dose in 24 hours.
Keep a list of your or your child’s medicines and show it to your healthcare provider and pharmacist when you get a new medicine. Take or give REVATIO exactly as your healthcare provider tells you.
Comparing the Mechanism of Action
REVATIO® (re-VAH-tee-oh) (sildenafil) oral suspension What is the most important information I should know about REVATIO? Never take REVATIO with any nitrate or guanylate cyclase stimulator medicines. Your blood pressure could drop quickly to an unsafe level. Nitroglycerin in any form including tablets, patches, sprays, and ointments Street drugs called “poppers” (amyl nitrate, butyl nitrate or nitrite) Riociguat, a medicine that treats pulmonary arterial sildenafil pick up hypertension and chronic thromboembolic pulmonary hypertension. Ask your healthcare provider or pharmacist if you are not sure if you or your child are taking a nitrate or a guanylate cyclase stimulator medicine.
Usual Geriatric Dose for:
See “What are the possible side effects of REVATIO?” for more information about side effects. REVATIO is a prescription medicine used to treat pulmonary arterial hypertension (PAH). PAH is a type of high blood pressure in the arteries of your lungs. adults to improve your ability to exercise and help slow down the worsening of your physical condition. children 1 to 17 years old to improve their ability to exercise, and in children too young to do certain exercise and lung testing. Your healthcare provider may change your or your child’s dose of REVATIO as needed.
Clinical Pharmacology for Revatio
The sildenafil medium and high dose groups displayed mPAP changes from baseline compared to placebo, of -3.5 mmHg (95% CI: -8.9, 1.9) and -7.3 mmHg (95% CI: -12.4, -2.1), respectively; while the low dose group showed little difference from placebo (difference of 1.6 mmHg [95% CI: -4.5, 7.6]). Improvements were observed with cardiac index with all three sildenafil groups over placebo, 10%, 4%, and 15% for the low, medium, and high dose groups, respectively [see CLINICAL PHARMACOLOGY]. Of the 234 pediatric patients treated in the short-term, placebo-controlled study, 220 patients entered the long-term extension study. Patients who had been in the placebo group in the shortterm study were randomly reassigned to sildenafil treatment; patients weighing ≥ 20 kg entered the medium or high dose groups (1:2), while patients weighing > 20 kg entered the low, medium, or high dose groups (1:1:1). Of the total 229 patients who received sildenafil, there were 55, 74, and 100 patients in the low, medium, and high dose groups, respectively.
Incidence not known
Across the short-term and long-term studies, the overall duration of treatment from start of double-blind for individual patients ranged from 3 to 3,129 days. By sildenafil treatment group, median duration of sildenafil treatment was 1,696 days (excluding the 5 patients who received placebo in double-blind and were not treated in the long-term extension study). Peak VO2 was assessed 1 year after the start of the placebo-controlled study. Of sildenafil-treated patients developmentally able to perform the CPET 59/114 patients (52%) had not shown any deterioration in PVO2 from start of sildenafil. Similarly, 191 of 229 patients (83%) who had received sildenafil had either maintained or improved their WHO Functional Class at 1 year assessment. Do not change your dose or stop taking REVATIO without talking to your healthcare provider.
| Side Effect | Severity | Frequency | Notes |
|---|---|---|---|
| Headache | Mild to moderate | Common | Usually subsides within hours |
| Flushing | Mild | Frequent | Redness of face or neck |
| Nasal Congestion | Mild | Common | Stuffiness in nasal passages |
REVATIO may be prescribed to you as REVATIO tablets or REVATIO oral suspension. Take your prescribed dose of REVATIO tablets or oral suspension 3 times a day. See the detailed Instructions for Use that comes with REVATIO oral suspension for information on how to take or give REVATIO oral suspension. REVATIO oral suspension will be mixed for you by your pharmacist.
Is Sildenafil Safe?
Kaplan-Meier estimates of survival at 3 years in patients > 20 kg in weight at baseline were 94%, 93%, and 85% in the low, medium, and high dose groups, respectively; for patients ≥ 20 kg in weight at baseline, the survival estimates were 94% and 93% for patients in the medium and high dose groups, respectively [see Use In Specific Populations and ADVERSE REACTIONS]. A study to assess the effects of multiple doses of sildenafil on mortality in adults with PAH was conducted following the observation of a higher risk of mortality in pediatric patients taking a high dose of REVATIO TID, based on body weight, compared to those taking a lower dose of REVATIO in the long-term extension of the pediatric clinical trial. The study was a randomized, double-blind, parallel-group study in 385 adults with PAH. Patients were randomly assigned 1:1:1 to one of three treatment groups (5, 20, and 80 mg TID). Most patients were PAH treatment naïve (83%).
Special Populations
For most patients the etiology of PAH was idiopathic (72%). The most common WHO Functional Class was Class III (58% of patients). Treatment groups were well balanced with respect to baseline demographics of strata history of PAH treatment and etiology of PAH, as well as the WHO Functional Class categories. The primary objective of the study was to compare sildenafil 80 mg TID versus 5 mg TID for mortality, with success defined by ruling out twice the mortality at 80 mg. The key secondary efficacy endpoint was time to first event of clinical worsening, defined as a composite endpoint of all-cause mortality, hospitalization for worsening PAH or disease progression. Do not mix REVATIO oral suspension with other medicine or flavoring.
| Key Point | Explanation | Advice |
|---|---|---|
| Take on an empty stomach or after light meal | Food may delay absorption | Wait at least 1 hour after eating |
| Do not combine with nitrates | Severe hypotension risk | Consult doctor before combining |
| Alcohol consumption | May decrease effectiveness or cause side effects | Limit or avoid alcohol during use |
| Seek medical advice for persistent side effects | To ensure safe use and address concerns | Contact healthcare provider if needed |
If you or your child take too much REVATIO, call your healthcare provider or go to the nearest hospital emergency room right away.
- Sildenafil has been shown to improve erectile function.
- It was originally developed for pulmonary hypertension.
- Unexpected side effects should be reported to a doctor.
- Avoid using other ED medications simultaneously.
What are the possible side effects of REVATIO?
| Region | Approximate Cost per Tablet | Notes |
|---|---|---|
| USA | $10 - $15 | Generic options available |
| Europe | €8 - €12 | Varies by pharmacy |
| Australia | AUD 15 - 20 | Usually prescription-based |
| India | $1 - $3 | Generic widely available |
REVATIO may cause serious side effects, including: See “What is the most important information I should know about REVATIO?” REVATIO may cause low blood pressure that last for a short time. If you take medicines to treat high blood pressure, your healthcare provider should monitor your blood pressure during treatment with REVATIO. Decreased eyesight or permanent loss of vision in one or both eyes can be a sign of non-arteritic anterior ischemic optic neuropathy (NAION). Most people who develop NAION have certain risk factors.
- Consult your healthcare provider before starting sildenafil.
- Monitor blood pressure regularly if prescribed anticoagulants.
- Be cautious with activities requiring alertness post-dose.
- Treatment should be part of a broader health plan.
You can ask your healthcare provider if you have questions about risk factors for NAION. If you notice a sudden decrease or loss of vision in one or both eyes during treatment with REVATIO, contact your healthcare provider right away.