Vardenafil 5 mg Compared to Other PDE5 Inhibitors

Adverse Effects
How RedBox Rx can help
Usual Geriatric Dose for Erectile Dysfunction
Vardenafil side effects
See also:
Vardenafil dosing information
Advancing Effective Research Policy

idelalisibidelalisib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Adverse Effects

buprenorphine transdermal and vardenafil both increase QTc interval. buprenorphine, long-acting injectionbuprenorphine, long-acting injection and vardenafil both increase QTc interval. buprenorphine, long-acting injection and vardenafil both increase QTc interval. carbamazepinecarbamazepine will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. carbamazepine will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

What should I do if I accidentally take too much vardenafil?

ceritinib and vardenafil both increase QTc interval. clarithromycinclarithromycin and vardenafil both increase QTc interval. clarithromycin and vardenafil both increase QTc interval. danazoldanazol will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. danazol will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates idelalisib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates iloperidonevardenafil and iloperidone both increase QTc interval.

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isoflurane and vardenafil both increase QTc interval. itraconazoleitraconazole and vardenafil both increase QTc interval. itraconazole and vardenafil both increase QTc interval. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies.

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Vardenafil preclinical trial data: potency, pharmacodynamics, pharmacokinetics, and adverse events. 10 mg PO ~1 hour before sexual activity; may be increased to 20 mg or reduced to 5 mg, depending on effectiveness and tolerance; not to exceed 1 dose/day TabletKetoconazole 200 mg/day or itraconazole 200 mg/day: Vardenafil dosage not to exceed 5 mg/dayIndinavir, saquinavir, atazanavir, clarithromycin, ketoconazole 400 mg/day or itraconazole 400 mg/day: Vardenafil dosage not to exceed 2.5 mg/dayRitonavir (600 mg q12hr) or cobicistat: Vardenafil dosage not to exceed 2.5 mg/72 hrErythromycin 500 mg q8hr: Vardenafil dosage not to exceed 5 mg/day Ketoconazole 200 mg/day or itraconazole 200 mg/day: Vardenafil dosage not to exceed 5 mg/day Indinavir, saquinavir, atazanavir, clarithromycin, ketoconazole 400 mg/day or itraconazole 400 mg/day: Vardenafil dosage not to exceed 2.5 mg/day Ritonavir (600 mg q12hr) or cobicistat: Vardenafil dosage not to exceed 2.5 mg/72 hr Erythromycin 500 mg q8hr: Vardenafil dosage not to exceed 5 mg/day Oral disintegrating tablet (ODT)Strong or moderate CYP3A4 inhibitors: Do not use (unable to adjust vardenafil dose) Strong or moderate CYP3A4 inhibitors: Do not use (unable to adjust vardenafil dose) Only initiate vardenafil if stabilized on alpha-blocker Stabilized on alpha-blocker therapy (eg, alfuzosin, terazosin, tamsulosin): 5 mg/day PO initially Stabilized on alpha-blocker therapy and taking moderate-to-strong CYP3A4 inhibitor: 2.5 mg/day PO initially Consider time interval between dosing when vardenafil is concomitantly used with alpha-blocker therapy Mild-to-severe: No dosage adjustment necessary Mild (Child-Pugh A): No dosage adjustment necessary Moderate (Child-Pugh B): Start 5mg PO ~1 hr before sexual activity; not to exceed 10 mg once daily Severe (Child-Pugh C): Do not use Mild (Child-Pugh A): No dosage adjustment necessary Moderate-to-severe (Child-Pugh B or C): Do not use Orphan designation for treatment of pulmonary arterial hypertension Respira Therapeutics, Inc; 5901 Indian School Road NE, suite 107; Albuquerque, New Mexico 87110 Film-coated tablet: 10 mg PO ~1 hour before sexual activity; may be increased to 20 mg or reduced to 5 mg, depending on effectiveness and tolerance; not to exceed 1 dose/day Orally disintegrating tablet (ODT): 10 mg PO placed on tongue ~1 hour before sexual activity; not to exceed 1 dose/day; not interchangeable with 10-mg film-coated tablet; if higher or lower doses required, film-coated tablet should be prescribed AUC and Cmax increased by 39% and 21%, respectively, in elderly men (compared with men <45 years) lefamulinlefamulin will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval. lefamulin will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nitroglycerin rectalvardenafil increases effects of nitroglycerin rectal by additive vasodilation.

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Use of nitroglycerin within a few days of PDE5 inhibitors is contraindicated. PDE5 inhibitors have been shown to potentiate the hypotensive effects of organic nitrates. vardenafil increases effects of nitroglycerin rectal by additive vasodilation. Either increases effects of the other by additive vasodilation. Coadministration of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil) and guanylate cyclase stimulators (eg, riociguat) is contraindicated due to risk of additive hypotension. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.

Usual Geriatric Dose for Erectile Dysfunction

doxazosinvardenafil increases effects of doxazosin by pharmacodynamic synergism. vardenafil increases effects of doxazosin by pharmacodynamic synergism. entrectinib and vardenafil both increase QTc interval. eribulin and vardenafil both increase QTc interval. Avoid coadministration of fexinidazole with drugs fildena tablet known to block potassium channels and/or prolong QT interval.

Semantic Clinical Drug (SCD): Vardenafil 5 mg Oral Tablet (Atom ID: 1543052)

givinostatvardenafil and givinostat both increase QTc interval. If unable to avoid coadministration, obtain ECGs when initiating, during concomitant use, and as clinically indicated. Withhold if QTc interval >500 ms or a change from baseline >60 ms. vardenafil and givinostat both increase QTc interval. hydroxychloroquine sulfate and vardenafil both increase QTc interval. macimorelinmacimorelin and vardenafil both increase QTc interval.

Vardenafil 5 mg is available in tablet form for oral use.
It is important to complete the full course unless advised otherwise.
The medication’s effect can be delayed or reduced by certain foods.
Regular medical follow-up enhances safe use.
Patients should inform the doctor of all medications they are taking.
Its efficacy can be reduced by smoking or excessive alcohol.
Use with caution in elderly patients due to increased sensitivity.
Label instructions should be carefully read before use.
Over-the-counter use without consultation is discouraged.
Vardenafil 5 mg does not protect against pregnancy or STDs.
Maintain a healthy weight to improve medication effectiveness.
Report any allergic reactions like rash or swelling immediately.

Macimorelin causes an increase of ~11 msec in the corrected QT interval.

Vardenafil side effects

apalutamideapalutamide will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.

Patient resources

apalutamide will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. artemether and vardenafil both increase QTc interval. asenapineasenapine and vardenafil both increase QTc interval. asenapine and vardenafil both increase QTc interval. asenapine transdermalasenapine transdermal and vardenafil both increase QTc interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia.

Vardenafil 5 mg is effective in treating primary and secondary ED.
It is marketed under various brand names worldwide.
Generic Vardenafil 5 mg is usually more affordable.
It is not suitable for individuals with certain eye conditions.
Possible side effects include nasal congestion or dizziness.
Use with caution if you have kidney or liver issues.
Consultation with a healthcare provider is essential before use.
Vardenafil 5 mg does not provide protection from sexually transmitted infections.
Keep medical records updated when taking this medication.
Never share your medication with others.
It is important to have realistic expectations about treatment.
Follow-up appointments help monitor efficacy and safety.

Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin. macimorelin and vardenafil both increase QTc interval.

Vardenafil dosing information

asenapine transdermal and vardenafil both increase QTc interval. Either increases effects of the other by Other (see comment). Comment: Avoid combination; duplicate therapy is not recommended. buprenorphinebuprenorphine and vardenafil both increase QTc interval. buprenorphine and vardenafil both increase QTc interval.

Key Takeaways

buprenorphine buccalbuprenorphine buccal and vardenafil both increase QTc interval. buprenorphine buccal and vardenafil both increase QTc interval. buprenorphine subdermal implantbuprenorphine subdermal implant and vardenafil both increase QTc interval. buprenorphine subdermal implant and vardenafil both increase QTc interval. buprenorphine transdermalbuprenorphine transdermal and vardenafil both increase QTc interval. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. mefloquine increases toxicity of vardenafil by QTc interval.

Vardenafil 5 mg may be less effective if taken with high-fat meals.
Side effects like indigestion or muscle aches are possible.
Inform your doctor about any allergic reactions experienced.
Be cautious if you have low blood pressure or heart disease.
It is recommended to avoid taking other ED medications concurrently.
Regular check-ups help assess medication effectiveness.
Discontinue use and seek help if adverse reactions occur.
The medication can improve intimacy confidence and quality.
Use the lowest effective dose to minimize side effects.
Vardenafil 5 mg is generally safe when used responsibly.
Keep out of reach of children and pets.
Consult your healthcare provider for personalized advice.

vardenafil and milsaperidone both increase QTc interval.

Side Effect	Frequency	Severity	Management Tips
Headache	Common	Mild to Moderate	Hydration, OTC pain relief
Flushing	Frequently reported	Mild	Cool environment, calming techniques
Nasal congestion	Sometimes	Mild	Decongestants (if advised)
Dizziness	Occasionally	Mild	Sit or lie down, avoid driving
Upset stomach	Less common	Mild	Take with food, monitor symptoms

moxisylytevardenafil increases effects of moxisylyte by pharmacodynamic synergism.

Step	Description	Tips
Taking the medication	Take orally with a glass of water	Can be taken with or without food
Timing before sexual activity	30-60 minutes prior	Avoid heavy fatty meal initially
Duration of effect	Up to 4-5 hours, depending on individual	Be aware of your response
Do not exceed prescribed dose	Usually 5 mg per dose, once per day	Overdose risks and side effects

vardenafil increases effects of moxisylyte by pharmacodynamic synergism. ondansetronondansetron and vardenafil both increase QTc interval.

Advancing Effective Research Policy

Either increases effects of the other by pharmacodynamic synergism. Coadministration of vericiguat with PDE-5 inhibitors may result in additive hypotensive effects. Either increases effects of the other by QTc interval. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.

Are you currently using Vardenafil (Levitra, Staxyn)?

alfuzosinvardenafil increases effects of alfuzosin by pharmacodynamic synergism. vardenafil increases effects of alfuzosin flibanserin by pharmacodynamic synergism. amisulprideamisulpride and vardenafil both increase QTc interval. amisulpride and vardenafil both increase QTc interval. anagrelide and vardenafil both increase QTc interval.