7 DRUG INTERACTIONS

Forward-looking statements speak only as of the date on which they are made, and we assume no obligation to update or revise any forward-looking statements or other information contained herein, whether as a result of new information, future events or otherwise.

• Sildenafil generics are often produced by multiple pharmaceutical companies worldwide.
• These generics undergo strict quality control before reaching the market.
• The cost of generic sildenafil is usually 60-80% less than branded Viagra.
• Use of generic sildenafil can improve sexual function with reduced medication expense.
• Patients should consult doctors before starting sildenafil generics.
• Generic sildenafil should be taken approximately 30-60 minutes before activity.

You are cautioned not to rely on these forward-looking statements. You are advised to consult any additional disclosures we make in our reports to the SEC on Form 6-K, as well as the cautionary discussion of risks and uncertainties under “Risk Factors” in our Annual Report. These are factors that we believe could cause our actual results to differ materially from expected results. Other factors besides those listed could also materially and adversely affect us. This discussion is provided as permitted by the Private Securities Litigation Reform Act of 1995.

Brand Name	Price per 50 mg Tablet	Average Monthly Cost	Cheaper Than Brand Name?
Kamagra	$0.15	$4.50	Yes
Sildenafil Citrate	$0.20	$6.00	Yes
Viagra (Brand)	$1.00	$30.00	No
Caverta	$0.18	$5.40	Yes

1 Viagra® is a registered trademark of Pfizer Inc.2 Revatio® is a registered trademark of Pfizer Inc. Teva Pharmaceutical Industries Ltd.IR Contacts:United StatesKevin C. Mannix, 215-591-8912Ran Meir, 215-591-3033orIsraelTomer Amitai, 972 (3) 926-7656orPR Contacts:IsraelIris Beck Codner, 972 (3) 926-7208orUnited StatesDenise Bradley, 215-591-8974 Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a man get and keep an erection. Sildenafil does not protect against sexually transmitted diseases (such chew sildenafil as HIV, hepatitis B, gonorrhea, syphilis). Practice "safe sex" such as using latex condoms.

1. Answer quick questions

Consult your doctor or pharmacist for more details. Sildenafil is also available in other brands and strengths for treating high blood pressure in the lungs (pulmonary hypertension). Do not take sildenafil with any other product that contains sildenafil or other similar medications for erectile dysfunction-ED or pulmonary hypertension (such as tadalafil, vardenafil). Sildenafil is available under the following different brand names: Revatio, and Viagra.

• Generic sildenafil is often dispensed in 10, 20, or 25 tablets per pack.
• It is essential to complete the full course as prescribed by a healthcare professional.
• Patients should inform their doctor of any other medications they are taking.
• Sildenafil generics can be used by both younger and older men under medical advice.
• Price comparison can help find the most affordable sildenafil generic option.
• Proper communication with your healthcare provider ensures safe use.

Dosage Considerations – Should be Given as Follows: 50 mg orally 1 hour before sexual activity may be increased to 100 mg or reduced to 25 mg, depending on effectiveness and tolerance Oral: 5 mg or 20 mg 3 times daily, administered 4-6 hours apart Intravenous (IV): 2.5-mg or 10-mg bolus 3 times daily if patient is temporarily unable to take orally Recommended oral/IV dose not to be exceeded Adding Revatio to bosentan does not have any beneficial effect on exercise capacity Hepatic impairment or severe renal impairment: Use initial dose of 25 mg Older than 65 years: 25 mg orally initially 1 hour before sexual activity Oral: 5 mg or 20 mg 3 times daily, administered 4-6 hours apart Intravenous (IV): 2.5-mg or 10-mg bolus 3 times daily if patient is temporarily unable to take orally Recommended oral/IV dose not to be exceeded Adding Revatio to bosentan does not have any beneficial effect on exercise capacity Clinical trials found no significant difference in response between elderly patients and younger adults; however, cautious dose selection should be considered in elderly because of greater frequency of decreased hepatic, renal, and cardiac function, as well as comorbid conditions and concomitant pharmacotherapy Compared with healthy younger volunteers, healthy elderly volunteers (65 years and older) had reduced clearance of sildenafil, resulting in approximately 84% and 107% higher plasma concentrations of sildenafil and its active N-desmethyl metabolite, respectively Not to be prescribed to children (1-17 years) for pulmonary arterial hypertension (PAH); this recommendation against use is based on long-term clinical pediatric trial showing that children taking high doses had higher risk of death than children taking low doses and that low doses were not effective in improving exercise ability Side effects associated with use of Sildenafil, include the following: Postmarketing side effects of sildenafil reported include: Vaso-occlusive crisis (PAH secondary to sickle-cell anemia) This document does not contain all possible side effects and others may occur.

Product	Dosage	Quantity + Bonus	Price
Kamagra Oral Jelly	100mg	90 + 8 Sachets	303.56€ 289.10€	Buy
Viagra Generic	150mg	60 + 4 Pills	111.25€ 105.95€	Buy
Viagra Generic	200mg	30 + 2 Pills	83.07€ 79.11€	Buy
Viagra Generic	200mg	60 + 4 Pills	125.19€ 119.23€	Buy
Kamagra Polo	100mg	60 + 4 Pills	189.39€ 180.37€	Buy
Viagra Generic	50mg	90 + 6 Pills	107.37€ 102.26€	Buy
Viagra Generic	150mg	120 + 8 Pills	177.58€ 169.12€	Buy
Kamagra Polo	100mg	20 Pills	83.56€ 79.58€	Buy
Viagra Generic	150mg	10 Pills	36.73€ 34.98€	Buy
Viagra Generic	50mg	60 + 4 Pills	83.93€ 79.93€	Buy
Viagra Generic	200mg	10 Pills	40.96€ 39.01€	Buy
Viagra Generic	25mg	10 Pills	25.19€ 23.99€	Buy
Viagra Generic	150mg	180 + 10 Pills	236.46€ 225.20€	Buy
Viagra Generic	100mg	60 + 4 Pills	96.36€ 91.77€	Buy
Kamagra Polo	100mg	180 + 8 Pills	446.52€ 425.26€	Buy
Kamagra Polo	100mg	120 + 6 Pills	327.15€ 311.57€	Buy

Check with your physician for additional information about side effects. If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware sildenafil tablet manforce 50 mg of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first. Sildenafil has serious interactions with at least 48 different drugs.

Understanding Sildenafil

Sildenafil (Liqrev, Revatio) is used to improve the ability to exercise in adults (Liqrev, Revatio) and children 1 year of age and older (Revatio) with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Sildenafil is in a class of medications called phosphodiesterase (PDE) inhibitors. Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Sildenafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow easily.

Sildenafil: what you need to know

Sildenafil has moderate interactions with at least 72 different drugs.

Do you need a prescription for generic Viagra?

Does Viagra work to treat ED?

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional sildenafil pink pill or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

• Sildenafil generic is a popular choice for ED treatment worldwide.
• It provides a less expensive yet effective solution for erectile issues.
• The drug's popularity has increased due to patent expiration of brand-name Viagra.
• Always check for proper licensing and approval before purchasing.
• Consulting a healthcare provider ensures the correct dosage and safety.
• Many online sources offer genuine sildenafil generics with verified credentials.

Do not take Revatio or Viagra if you are allergic to sildenafil or any ingredients contained in this drug. In case of overdose, get medical help or contact a Poison Control Center immediately Soluble guanylate cyclase (sGC) stimulators (e.g., riociguat); concomitant use can cause hypotension Co-administration with nitrates (either regularly and/or intermittently) and nitric oxide donors Consistent with the effects of PDE5 inhibition on the nitric oxide/cyclic guanosine monophosphate pathway, PDE5 inhibitors may potentiate the hypotensive effects of nitrates A suitable time interval following PDE5 dosing for the safe administration of nitrates or nitric oxide donors has not been determined Elicits vasodilatory properties, resulting in mild and transient decreases in blood pressure. See "What Are Side Effects Associated with Using Sildenafil?" Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi See "What Are Side Effects Associated with Using Sildenafil?” Elicits vasodilatory properties, resulting in mild and transient decreases in blood pressure Use with caution in patients with anatomic deformation of penis (e.g., angulation, cavernosal fibrosis, or Peyronie disease), conditions potentially predisposing to priapism (e.g., sickle cell anemia, multiple myeloma, or leukemia), cardiovascular disease, bleeding disorders, active peptic ulcer disease, liver disease, renal impairment, multidrug antihypertensive regimens, retinitis pigmentosa, concomitant use of CYP3A4 inhibitors Pulmonary vasodilators may significantly worsen cardiovascular status of patients with pulmonary veno-occlusive disease Patients taking alpha blocker should be stabilized before starting phosphodiesterase (PDE)-5 inhibitor, which should be initiated at lowest dose; if patient is already taking optimized dose of PDE-5 inhibitor, alpha blocker should be initiated at lowest dose to avoid hypotension Not to be taken with other PDE-5 inhibitors Sudden decrease or loss of hearing, which may be accompanied by tinnitus and dizziness Viagra: Patients should stop sildenafil and seek medical care if a sudden loss of vision occurs in 1 or both eyes, which could be a sign of non-arteritic anterior ischemic optic neuropathy (NAION); use with caution, and only when the anticipated benefits outweigh the risks, in patients with a history of NAION; patients with a ”crowded” optic disc may also be at an increased risk of NAION Viagra: Potential for cardiac risk with sexual activity in patients with preexisting cardiovascular disease; therefore, treatment for erectile dysfunction generally should not be instituted in men for whom sexual activity is inadvisable because of their underlying cardiovascular status May cause dose-related impairment of color discrimination; use caution in patients with retinitis pigmentosa Evaluate underlying causes of erectile dysfunction or BPH before initiating therapy Revatio: In small, prematurely terminated study of patients with PAH secondary to sickle-cell disease, vaso-occlusive crises requiring hospitalization were more commonly reported by patients who received sildenafil than by those randomized to placebo; effectiveness of sildenafil in PAH secondary to sickle-cell anemia has not been established; the clinical relevance to men treated for erectile dysfunction with sildenafil is not known Revatio: Not for use in children with PAH; increased mortality with increasing doses (hazard ratio 3.5) was observed in randomized, double-blind, placebo-controlled clinical trial of 234 children (1-17 years) with PAH who had mild-to-moderate symptoms at baseline Revatio: Epistaxis occurred in 13% of patients with PAH secondary to connective tissue disease (e.g., scleroderma); this effect was not seen in idiopathic PAH; incidence was also higher in those receiving concomitant PO vitamin K antagonist therapy (9%) than in those not receiving such therapy (2%) Sildenafil may be acceptable for use during pregnancy Either animal studies show no risk but human studies are not available, or animal studies showed minor risks and human studies were done and showed no risk It is unknown whether sildenafil is distributed into breast milk. Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men.

MeSH terms

Forward-looking statements speak only as of the date on which they are made, and we assume no obligation to update or revise any forward-looking statements or other information contained herein, whether as a result of new information, future events or otherwise. You are cautioned not to rely on these forward-looking statements. You are advised to consult any additional disclosures we make in our reports to the SEC on Form 6-K, as well as the cautionary discussion of risks and uncertainties under “Risk Factors” in our Annual Report. These are factors that we believe could cause our actual results to differ materially from expected results. Other factors besides those listed could also materially and adversely affect us.

Apcalis SX Jelly

This discussion is provided as permitted by the Private Securities Litigation Reform Act of 1995. 1 Viagra® is a registered trademark of Pfizer Inc.2 Revatio® is a registered trademark of Pfizer Inc. Teva Pharmaceutical Industries Ltd.IR Contacts:United StatesKevin C. Mannix, 215-591-8912Ran Meir, 215-591-3033orIsraelTomer Amitai, 972 (3) 926-7656orPR Contacts:IsraelIris Beck Codner, 972 (3) 926-7208orUnited StatesDenise Bradley, 215-591-8974 Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a man get and keep an erection. Sildenafil (Liqrev, Revatio) is used to improve the ability to exercise in adults (Liqrev, Revatio) and children 1 year of age and older (Revatio) with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Sildenafil is in a class of medications called phosphodiesterase (PDE) inhibitors. Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual stimulation.

How to avoid counterfeit generic Viagra

Sildenafil has serious interactions with at least 48 different drugs. Sildenafil has moderate interactions with at least 72 different drugs. This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist.

What are the serious side effects of sildenafil?

Check with your health care professional sildenafil pink pill or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine. Do not take Revatio or Viagra if you are allergic to sildenafil or any ingredients contained in this drug. In case of overdose, get medical help or contact a Poison Control Center immediately Soluble guanylate cyclase (sGC) stimulators (e.g., riociguat); concomitant use can cause hypotension Co-administration with nitrates (either regularly and/or intermittently) and nitric oxide donors Consistent with the effects of PDE5 inhibition on the nitric oxide/cyclic guanosine monophosphate pathway, PDE5 inhibitors may potentiate the hypotensive effects of nitrates A suitable time interval following PDE5 dosing for the safe administration of nitrates or nitric oxide donors has not been determined Elicits vasodilatory properties, resulting in mild and transient decreases in blood pressure. See "What Are Side Effects Associated with Using Sildenafil?" Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi See "What Are Side Effects Associated with Using Sildenafil?” Elicits vasodilatory properties, resulting in mild and transient decreases in blood pressure Use with caution in patients with anatomic deformation of penis (e.g., angulation, cavernosal fibrosis, or Peyronie disease), conditions potentially predisposing to priapism (e.g., sickle cell anemia, multiple myeloma, or leukemia), cardiovascular disease, bleeding disorders, active peptic ulcer disease, liver disease, renal impairment, multidrug antihypertensive regimens, retinitis pigmentosa, concomitant use of CYP3A4 inhibitors Pulmonary vasodilators may significantly worsen cardiovascular status of patients with pulmonary veno-occlusive disease Patients taking alpha blocker should be stabilized before starting phosphodiesterase (PDE)-5 inhibitor, which should be initiated at lowest dose; if patient is already taking optimized dose of PDE-5 inhibitor, alpha blocker should be initiated at lowest dose to avoid hypotension Not to be taken with other PDE-5 inhibitors Sudden decrease or loss of hearing, which may be accompanied by tinnitus and dizziness Viagra: Patients should stop sildenafil and seek medical care if a sudden loss of vision occurs in 1 or both eyes, which could be a sign of non-arteritic anterior ischemic optic neuropathy (NAION); use with caution, and only when the anticipated benefits outweigh the risks, in patients with a history of NAION; patients with a ”crowded” optic disc may also be at an increased risk of NAION Viagra: Potential for cardiac risk with sexual activity in patients with preexisting cardiovascular disease; therefore, treatment for erectile dysfunction generally should not be instituted in men for whom sexual activity is inadvisable because of their underlying cardiovascular status May cause dose-related impairment of color discrimination; use caution in patients with retinitis pigmentosa Evaluate underlying causes of erectile dysfunction or BPH before initiating therapy Revatio: In small, prematurely terminated study of patients with PAH secondary to sickle-cell disease, vaso-occlusive crises requiring hospitalization were more commonly reported by patients who received sildenafil than by those randomized to placebo; effectiveness of sildenafil in PAH secondary to sickle-cell anemia has not been established; the clinical relevance to men treated for erectile dysfunction with sildenafil is not known Revatio: Not for use in children with PAH; increased mortality with increasing doses (hazard ratio 3.5) was observed in randomized, double-blind, placebo-controlled clinical trial of 234 children (1-17 years) with PAH who had mild-to-moderate symptoms at baseline Revatio: Epistaxis occurred in 13% of patients with PAH secondary to connective tissue disease (e.g., scleroderma); this effect was not seen in idiopathic PAH; incidence was also higher in those receiving concomitant PO vitamin K antagonist therapy (9%) than in those not receiving such therapy (2%) Sildenafil may be acceptable for use during pregnancy Either animal studies show no risk but human studies are not available, or animal studies showed minor risks and human studies were done and showed no risk It is unknown whether sildenafil is distributed into breast milk. Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. This increased blood flow can cause an erection.

Does Viagra Work the Same as Generic Sildenafil?

Sildenafil does not protect against sexually transmitted diseases (such chew sildenafil as HIV, hepatitis B, gonorrhea, syphilis). Practice "safe sex" such as using latex condoms. Consult your doctor or pharmacist for more details. Sildenafil is also available in other brands and strengths for treating high blood pressure in the lungs (pulmonary hypertension). Do not take sildenafil with any other product that contains sildenafil or other similar medications for erectile dysfunction-ED or pulmonary hypertension (such as tadalafil, vardenafil).

When to talk to a doctor

Sildenafil is available under the following different brand names: Revatio, and Viagra. Dosage Considerations – Should be Given as Follows: 50 mg orally 1 hour before sexual activity may be increased to 100 mg or reduced to 25 mg, depending on effectiveness and tolerance Oral: 5 mg or 20 mg 3 times daily, administered 4-6 hours apart Intravenous (IV): 2.5-mg or 10-mg bolus 3 times daily if patient is temporarily unable to take orally Recommended oral/IV dose not to be exceeded Adding Revatio to bosentan does not have any beneficial effect on exercise capacity Hepatic impairment or severe renal impairment: Use initial dose of 25 mg Older than 65 years: 25 mg orally initially 1 hour before sexual activity Oral: 5 mg or 20 mg 3 times daily, administered 4-6 hours apart Intravenous (IV): 2.5-mg or 10-mg bolus 3 times daily if patient is temporarily unable to take orally Recommended oral/IV dose not to be exceeded Adding Revatio to bosentan does not have any beneficial effect on exercise capacity Clinical trials found no significant difference in response between elderly patients and younger adults; however, cautious dose selection should be considered in elderly because of greater frequency of decreased hepatic, renal, and cardiac function, as well as comorbid conditions and concomitant pharmacotherapy Compared with healthy younger volunteers, healthy elderly volunteers (65 years and older) had reduced clearance of sildenafil, resulting in approximately 84% and 107% higher plasma concentrations of sildenafil and its active N-desmethyl metabolite, respectively Not to be prescribed to children (1-17 years) for pulmonary arterial hypertension (PAH); this recommendation against use is based on long-term clinical pediatric trial showing that children taking high doses had higher risk of death than children taking low doses and that low doses were not effective in improving exercise ability Side effects associated with use of Sildenafil, include the following: Postmarketing side effects of sildenafil reported include: Vaso-occlusive crisis (PAH secondary to sickle-cell anemia) This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects. If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware sildenafil tablet manforce 50 mg of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first. Sildenafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow easily.

Brand Name	Manufacturer	Country of Origin	Available Since	Price Range per Tablet
Sildenafil Citrate	BioPharma Inc.	India	2010	$0.20 - $0.50
Kamagra	Ajanta Pharma	India	2012	$0.15 - $0.40
Viagra (Generic)	Pfizer	USA	2014	$0.50 - $1.00
Sivagra	Drill Pharma	India	2013	$0.22 - $0.55